Het-PDB Navi2 (PDB: 2ALV)

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Ligands
Code	Name		Style	Show	Link
CY6	N-((3s,6r)-6-((S,E)-4-ethoxycarbonyl-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-ylcarbamoyl)-2,9-dimethyl-4-oxodec-8-en-3-yl)-5-methylisoxazole-3-carboxamide				PoSSuM

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Download interaction data: 2ALV

Code :

2ALV PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors

Release Data :

2006-08-08

Compound :

mol_id	molecule	chains	synonym
1	Replicase polyprotein 1ab	A	pp1ab, ORF1AB, Replicase polyprotein 1a
	ec: 3.4.22.- fragment: 3CL proteinase, residues 3242-3543

Source :

mol_id	organism_scientific	expression_system
1	SARS coronavirus (taxid:227859)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: SARS expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET11a

Authors :

Ghosh, A.K., Xi, K., Ratia, K., Santarsiero, B.D., Fu, W., Harcourt, B.H., Rota, P.A., Baker, S.C., Johnson, M.E., Mesecar, A.D.

Keywords :

SARS, coronavirus, 3C, 3Cl, 3CLpro, proteinase, protease, inhibitor, anti-viral, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

Ghosh, A.K.,Xi, K.,Ratia, K. et al.
(2005) J.Med.Chem. 48 : 6767 - 6771

Chain :	A
UniProt :	P59641 (multiple entry names are found)
Reaction :	-

PDB ID: 2ALV