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Ligands
Code Name Style Show Link
JNH 1-[2-(S)-amino-3-biphenyl-4-yl-propionyl]-pyrrolidine-2-(S)-carbonitrile
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
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Code : 2AJL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor
Release Data : 2005-11-08
Compound :
mol_id molecule chains synonym
1 Dipeptidyl peptidase 4 I,J Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Adenosine deaminase complexing protein 2, ADABP
ec: 3.4.14.5
fragment: Dipeptidyl peptidase 4 soluble form, residues 39-766
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: DPP4, ADCP2, CD26
expression_system_common: Cabbage looper
expression_system_vector_type: baculovirus
expression_system_plasmid: pFastBac
Authors : Qiao, L., Baumann, C.A., Crysler, C.S., Ninan, N.S., Abad, M.C., Spurlino, J.C., DesJarlais, R.L., Kervinen, J., Neeper, M.P., Bayoumy, S.S.
Keywords : Aminopeptidase, hydrolase, protease, serine protease
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

Qiao, L.,Baumann, C.A.,Crysler, C.S.  et al.
(2006)  Bioorg.Med.Chem.Lett.  16 : 123 - 128

PubMed: 16236500
DOI: 10.1016/j.bmcl.2005.09.037

Chain : I, J
UniProt : P27487 (DPP4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 PROSITE- ProRule:PRU10084, PubMed:10593948
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