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Ligands
Code Name Style Show Link
SO4 Sulfate ion
FKD 3-deoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid
Non-standard Residues
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Glycosylation
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Code : 2AGS   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Trypanosoma rangeli Sialidase in Complex with 2-Keto-3-deoxy-D-glycero-D-galacto-2,3-difluoro-nononic acid (2,3-difluoro-KDN)
Release Data : 2005-11-22
Compound :
mol_id molecule chains
1 sialidase A
ec: 3.2.1.18
fragment: residues 23-660
Source :
mol_id organism_scientific expression_system
1 Trypanosoma rangeli  (taxid:5698) Escherichia coli  (taxid:562)
expression_system_strain: TOP10
expression_system_vector_type: plasmid
expression_system_plasmid: pTrcHisA
Authors : Amaya, M.F., Alzari, P.M., Buschiazzo, A.
Keywords : beta-propeller, covalent enzyme-intermediate complex, beta-sandwich, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.700 Å )
Citation :

Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase.

Watts, A.G.,Oppezzo, P.,Withers, S.G.  et al.
(2006)  J.Biol.Chem.  281 : 4149 - 4155

PubMed: 16298994
DOI: 10.1074/jbc.M510677200

Chain : A
UniProt : O44049 (O44049_TRYRA)
Reaction : -