Brand  (β version)

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hetatm:

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centroid:
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Ligands
Code Name Link
CL Chloride ion
CH5 2-(((R)-2,3-dihydroxypropyl)phosphoryloxy)-N,N,N-trimethylethanaminium
DAO Lauric acid
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
IPA Isopropyl alcohol
LP3 (7r)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacosan-1-aminium 4-oxide
MYR Myristic acid
OLA Oleic acid
Code : 2AG2
Header : LIPID BINDING PROTEIN
Title : Crystal Structure Analysis of GM2-activator protein complexed with Phosphatidylcholine
Release Data : 2005-10-25
Compound :
mol_id molecule chains synonym
1 Ganglioside GM2 activator A,B,C GM2-AP
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
organ: LIVER, BRAIN, NEURONS
gene: GM2A
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET16b (Novagen)
Authors : Wright, C.S., Mi, L.Z., Lee, S., Rastinejad, F.
Keywords : phospholipid-protein complex, lipid acyl chain stacking, packaging, LIPID BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity.

Wright, C.S.,Mi, L.Z.,Lee, S.  et al.
(2005)  Biochemistry  44 : 13510 - 13521

PubMed: 16216074
DOI: 10.1021/bi050668w

Crystal Structure of Human GM2- Activator Protein with a Novel beta-cup Topology

Wright, C.S.,Li, S.C.,Rastinejad, F.
(2000)  J.Mol.Biol.  304 : 411 - 422

PubMed: 11090283
DOI: 10.1006/jmbi.2000.4225

Structure Analysis of Lipid Complexes of GM2-Activator Protein

Wright, C.S.,Zhao, Q.,Rastinejad, F.
(2003)  J.Mol.Biol.  331 : 951 - 964

PubMed: 12909021
DOI: 10.1016/S0022-2836(03)00794-0

Evidence for Lipid Packaging in the Crystal Structure of the GM2-Activator Complex with Platelet Activating Factor

Wright, C.S.,Mi, L.Z.,Rastinejad, F.
(2004)  J.Mol.Biol.  342 : 585 - 592

Chain : A, B, C
UniProt : P17900 (SAP3_HUMAN)
Reaction : -