Brand  (β version)

PDB ID: 2ABJ

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Ligands
Code Name Style Show Link
CBC N'-(5-chlorobenzofuran-2-carbonyl)-2-(trifluoromethyl)benzenesulfonohydrazide PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 2ABJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.
Release Data : 2006-06-27
Compound :
mol_id molecule chains synonym
1 Branched-chain-amino-acid aminotransferase, cytosolic A,D,G,J BCATc, ECA39 protein
ec: 2.6.1.42
fragment: BCAT(c)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BCAT1, BCT1, ECA39
Authors : Ohren, J.F., Moreland, D.W., Rubin, J.R., Hu, H.L., McConnell, P.C., Mistry, A., Mueller, W.T., Scholten, J.D., Hasemann, C.H.
Keywords : branched-chain-amino-acid aminotransferase, cytosolic, pyridoxal-phosphate-dependent aminotransferase, PLP-Lys220 Schiff base, inhibitor-bound, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

Hu, L.Y.,Boxer, P.A.,Kesten, S.R.  et al.
(2006)  Bioorg.Med.Chem.Lett.  16 : 2337 - 2340

PubMed: 16143519
DOI: 10.1016/j.bmcl.2005.07.058

Reaction

Chain : A, D, G, J
UniProt : P54687 (BCAT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L- glutamate 2.6.1.42 -
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2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate 2.6.1.42 -
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2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L- glutamate 2.6.1.42 -
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