Brand  (β version)

PDB ID: 2A7Q

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
CFB 2-chloro-9-(2-deoxy-2-fluoro-B -D-arabinofuranosyl)-9h-purin-6-amine PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2A7Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human dCK complexed with clofarabine and ADP
Release Data : 2006-01-24
Compound :
mol_id molecule chains synonym
1 Deoxycytidine kinase A dCK
ec: 2.7.1.74
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: DCK
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Zhang, Y., Secrist III, J.A., Ealick, S.E.
Keywords : alpha/beta parallel beta-sheet of 5 strands, transferase
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.

Zhang, Y.,Secrist, J.A.,Ealick, S.E.
(2006)  Acta Crystallogr.,Sect.D  62 : 133 - 139

PubMed: 16421443
DOI: 10.1107/S0907444905034293

Reaction

Chain : A
UniProt : P27707 (DCK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+) 2.7.1.74 PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175
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2'-deoxyadenosine + ATP = ADP + dAMP + H(+) 2.7.1.76 PubMed:18377927, PubMed:19159229, PubMed:1996353
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2'-deoxyguanosine + ATP = ADP + dGMP + H(+) 2.7.1.113 PubMed:19159229, PubMed:1996353
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