Brand  (β version)

PDB ID: 2A0C

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Ligands
Code Name Style Show Link
CK9 2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2A0C   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Release Data : 2006-01-24
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 2 X Cyclin dependant kinase 2, CDK2, p33 protein kinase
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
gene: CDK2
expression_system_vector_type: Baculovirus
Authors : Krystof, V., McNae, I.W., Walkinshaw, M.D., Fischer, P.M., Muller, P., Vojtesek, B., Orsag, M., Havlicek, L., Strnad, M.
Keywords : PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Krystof, V.,McNae, I.W.,Walkinshaw, M.D.  et al.
(2005)  Cell.Mol.Life Sci.  62 : 1763 - 1771

PubMed: 16003486
DOI: 10.1007/s00018-005-5185-1

Reaction

Chain : X
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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