Brand  (β version)

PDB ID: 2ZXM

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Ligands
Code Name Style Show Link
JB1 (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r,3s)-3-(2-hydroxyethyl)heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2ZXM   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : A New Class of Vitamin D Receptor Ligands that Induce Structural Rearrangement of the Ligand-binding Pocket
Release Data : 2009-02-17
Compound :
mol_id molecule chains synonym
1 Vitamin D3 receptor A VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1
fragment: Ligand binding domain, UNP residues 116-423
mol_id molecule chains synonym
2 Mediator of RNA polymerase II transcription subunit 1 C Mediator complex subunit 1
fragment: Drip 205 NR2 box peptide, UNP residues 624-636
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat ESCHERICHIA COLI  (taxid:562)
gene: Nr1i1, Vdr
expression_system_strain: C41
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-14B
mol_id organism_scientific
2
synthetic: yes
other_details: Synthetic peptide
Authors : Nakabayashi, M., Ikura, T., Ito, N.
Keywords : Nuclear receptor-antagonist complex, TRANSCRIPTION, DNA-binding, Metal-binding, Nucleus, Phosphoprotein, Receptor, Transcription regulation, Zinc, Zinc-finger, Activator
Exp. method : X-RAY DIFFRACTION ( 3.01 Å )
Citation :

A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor

Inaba, Y.,Yoshimoto, N.,Sakamaki, Y.  et al.
(2009)  J.Med.Chem.  52 : 1438 - 1449

PubMed: 19193059
DOI: 10.1021/jm8014348

Reaction

Chain : A
UniProt : P13053 (VDR_RAT)
Reaction : -
Chain : C
UniProt : A1L0Z0 (MED1_XENTR)
Reaction : -