Brand  (β version)

PDB ID: 2ZQD

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Ligands
Code Name Style Show Link
CAZ Acylated ceftazidime PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2ZQD   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Ceftazidime acyl-intermediate structure of class a beta-lact Toho-1 E166A/R274N/R276N triple mutant
Release Data : 2009-07-28
Compound :
mol_id molecule chains
1 Beta-lactamase Toho-1 A
ec: 3.5.2.6
mutation: E166A, R274N, R276N
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) ESCHERICHIA COLI  (taxid:562)
gene: bla
expression_system_vector_type: plasmid
expression_system_plasmid: PUC119
Authors : Nitanai, Y., Shimamura, T., Uchiyama, T., Ishii, Y., Takehira, M., Yutani, K., Matsuzawa, H., Miyano, M.
Keywords : EXTENDED-SPECTRUM, ESBL, BETA-LACTAMASE, ACYL-ENZYME COMPLEX, CEFTAZIDIME, TOHO-1, HYDROLASE, Antibiotic resistance, Plasmid
Exp. method : X-RAY DIFFRACTION ( 1.19 Å )
Citation :

Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates

Nitanai, Y.,Shimamura, T.,Uchiyama, T.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q47066 (BLT1_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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