Brand  (β version)

PDB ID: 2ZK6

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Ligands
Code Name Style Show Link
C08 Difluoro(5-{2-[(5-octyl-1h-pyrrol-2-yl-kappan)methylidene]-2h-pyrrol-5-yl-kappan}pentanoato)boron PoSSuM
Non-standard Residues
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Structure summary

Code : 2ZK6   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with C8-BODIPY
Release Data : 2009-02-24
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A,B PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
fragment: ligand binding domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: pparg
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Waku, T., Shiraki, T., Oyama, T., Fujimoto, Y., Morikawa, K.
Keywords : anti parallel helix sandwich, Activator, Diabetes mellitus, Disease mutation, DNA-binding, Metal-binding, Nucleus, Obesity, Phosphoprotein, Receptor, Transcription, Transcription regulation, Zinc-finger
Exp. method : X-RAY DIFFRACTION ( 2.41 Å )
Citation :

The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites

Waku, T.,Shiraki, T.,Oyama, T.  et al.
(2010)  Embo J.  29 : 3395 - 3407

PubMed: 20717101
DOI: 10.1038/emboj.2010.197

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -