PDB ID: 2ZJM
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Structure summary
Code : | 2ZJM PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide | ||||||||||||
Release Data : | 2009-01-20 | ||||||||||||
Compound : |
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Source : |
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Authors : | Allison, T.J., Pham, P., Romanowski, M.J., Munshi, S.K. | ||||||||||||
Keywords : | BACE, small-molecule inhibitor, fragment-based discovery, Alternative splicing, Aspartyl protease, Glycoprotein, Hydrolase, Membrane, Protease, Transmembrane, Zymogen | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.90 Å ) | ||||||||||||
Citation : |
Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
Yang, W.,Fucini, R.V.,Fahr, B.T.
et al.
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Reaction
Chain : | A | ||||||||
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UniProt : | P56817 (BACE1_HUMAN) | ||||||||
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