Brand  (β version)

PDB ID: 2ZIA

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Ligands
Code Name Style Show Link
CL9 2-chloro-2'-deoxyadenosine PoSSuM
UDP Uridine-5'-diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2ZIA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : C4S dCK variant of dCK in complex with cladribine+UDP
Release Data : 2008-07-08
Compound :
mol_id molecule chains synonym
1 Deoxycytidine kinase A,B dCK
ec: 2.7.1.74
mutation: C9S, C45S, C59S, C146S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DCK
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET14b
Authors : Sabini, E., Lavie, A.
Keywords : dCK, purine, deoxycytidine kinase, nucleoside, cladribine, 2-chloro-2'-deoxyadenosine, deoxyadenosine analog, UDP, ATP-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase

Sabini, E.,Hazra, S.,Konrad, M.  et al.
(2008)  J.Med.Chem.  51 : 4219 - 4225

PubMed: 18570408
DOI: 10.1021/jm800134t

Reaction

Chain : A, B
UniProt : P27707 (DCK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+) 2.7.1.74 PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175
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2'-deoxyadenosine + ATP = dAMP + ADP + H(+) 2.7.1.76 PubMed:18377927, PubMed:19159229, PubMed:1996353
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2'-deoxyguanosine + ATP = dGMP + ADP + H(+) 2.7.1.113 PubMed:19159229, PubMed:1996353
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