Brand  (β version)

PDB ID: 2ZHQ

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Ligands
Code Name Style Show Link
27U N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
TYS O-sulfo-L-tyrosine
Glycosylation
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Modification
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Structure summary

Code : 2ZHQ   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Thrombin Inhibition
Release Data : 2009-01-13
Compound :
mol_id molecule chains synonym
1 Thrombin light chain L Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
2 Thrombin heavy chain H Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
3 Hirudin variant-1 I Lepirudin
fragment: UNP Residues 54-64
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: blood plasma
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: blood plasma
mol_id organism_scientific
3 Hirudo medicinalis  (taxid:6421)
synthetic: yes
other_details: Synthetic Fragment of Hirudin from Hirudo Medicinalis
Authors : Baum, B., Heine, A., Klebe, G.
Keywords : Blood Clotting, Hydrolase Inhibitor, Acute phase, Blood coagulation, Cleavage on pair of basic residues, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Kringle, Protease, Secreted, Serine protease, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.96 Å )
Citation :

Non-additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry.

Baum, B.,Muley, L.,Smolinski, M.  et al.
(2010)  J.Mol.Biol.  397 : 1042 - 1054

PubMed: 20156458
DOI: 10.1016/j.jmb.2010.02.007

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P01050 (HIRV1_HIRME)
Reaction : -