Het-PDB Navi2 (PDB: 2Z5U)

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Ligands
Code	Name		Style	Show	Link
FAJ	Fad-trans-2-phenylcyclopropylamine adduct				PoSSuM

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Glycosylation
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Download interaction data: 2Z5U

Code :

2Z5U PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of Lysine-specific histone demethylase 1

Release Data :

2008-04-01

Compound :

mol_id	molecule	chains	synonym
1	Lysine-specific histone demethylase 1	A	Flavin-containing amine oxidase domain-containing protein 2, BRAF35-HDAC complex protein BHC110
	ec: 1.-.-.- fragment: LSD1, residues 172-833

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: KIAA0601, LSD1 expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pGEX-HS-6P

Authors :

Mimasu, S., Sengoku, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Keywords :

chromatin, histone demethylase, nucleosome, transcription, LSD1, Lysine-specific, Chromatin regulator, FAD, Nucleus, Oxidoreductase, Phosphorylation, Repressor, Transcription regulation, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI

Exp. method :

X-RAY DIFFRACTION ( 2.25 Å )

Citation :

Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A

Mimasu, S.,Sengoku, T.,Fukuzawa, S. et al.
(2008) Biochem.Biophys.Res.Commun. 366 : 15 - 22

PubMed: 18039463
DOI: 10.1016/j.bbrc.2007.11.066

PDB ID: 2Z5U

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