Brand  (β version)

PDB ID: 2Z2M

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
CDS (2r)-2-[(1r)-1-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-5-[(z)-2-(4-methyl-1,3-thiazol-5-yl)vinyl]-3,6-dihydro-2h-1,3-thiazine-4-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2Z2M   PDBj   RCSB PDB   PDBe
Header : BIOSYNTHETIC PROTEIN
Title : Cefditoren-Acylated Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae
Release Data : 2007-09-04
Compound :
mol_id molecule chains synonym
1 Penicillin-binding protein 2X A,D PBP-2X, PBP2X
fragment: UNP residues 71-238
other_details: N-TERMINAL DOMAIN
mol_id molecule chains synonym
2 Penicillin-binding protein 2X B,E PBP-2X, PBP2X
fragment: UNP residues 241-625
other_details: TRANSPEPTIDASE DOMAIN
mol_id molecule chains synonym
3 Penicillin-binding protein 2X C,F PBP-2X, PBP2X
fragment: UNP residues 626-750
other_details: C-TERMINAL DOMAIN
Source :
mol_id organism_scientific expression_system
1 Streptococcus pneumoniae  (taxid:1313) Escherichia coli  (taxid:562)
gene: pbpX
expression_system_vector_type: PLASMID
expression_system_plasmid: pET15b
mol_id organism_scientific expression_system
2 Streptococcus pneumoniae  (taxid:1313) Escherichia coli  (taxid:562)
gene: pbpX
expression_system_vector_type: PLASMID
expression_system_plasmid: pET15b
mol_id organism_scientific expression_system
3 Streptococcus pneumoniae  (taxid:1313) Escherichia coli  (taxid:562)
gene: pbpX
expression_system_vector_type: PLASMID
expression_system_plasmid: pET15b
Authors : Yamada, M., Watanabe, T., Takeuchi, Y.
Keywords : PEPTIDOGLYCAN SYNTHESIS, CELL WALL, PENICILLIN-BINDING, ANTIBIOTICS, CEFDITOREN, BIOSYNTHETIC PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity

Yamada, M.,Watanabe, T.,Miyara, T.  et al.
(2007)  Antimicrob.Agents Chemother.  51 : 3902 - 3907

PubMed: 17724158
DOI: 10.1128/AAC.00743-07

Reaction

Chain : C, F
UniProt : P59676 (PBPX_STRR6)
Reaction : -