Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
C Cytidine-5'-monophosphate
1PE Pentaethylene glycol
EDO 1,2-ethanediol
PO4 Phosphate ion
SO4 Sulfate ion
Modified Residues
Code Name Link
MSE Selenomethionine
Code : 2YK5
Header : TRANSFERASE
Title : Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with CMP.
Release Data : 2011-08-31
Compound :
mol_id molecule chains synonym
1 CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE A ALPHA 2\,3-ST, BETA-GALACTOSIDE ALPHA-2\,3-SIALYL TRANSFERASE, LIPOOLIGOSACCHARIDE SIALYLTRANSFERASE, LOS-SPECIFIC SIALYLTRANSFERASE
ec: 2.4.99.-
fragment: DELTA29NST, RESIDUES 49-370
Source :
mol_id organism_scientific expression_system
1 NEISSERIA MENINGITIDIS SEROGROUP B  (taxid:491) ESCHERICHIA COLI  (taxid:469008)
strain: 126E / NRCC4010
variant: L1 IMMUNOTYPE
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET-41B
Authors : Lin, L.Y.C., Rakic, B., Chiu, C.P.C., Lameignere, E., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.32 Å )
Citation :

Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis

Lin, L.Y.C.,Rakic, B.,Chiu, C.P.C.  et al.
(2011)  J.Biol.Chem.  286 : 37237

PubMed: 21880735
DOI: 10.1074/JBC.M111.249920

Chain : A
UniProt : P72097 (LST_NEIMB)
Reaction : CMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl- 2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.