Brand  (β version)

PDB ID: 2YBU

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
CX9 3,7-dimethyl-1-[3-(3-methyl-2,6-dioxo-9h-purin-1-yl)propyl]purine-2,6-dione PoSSuM
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Structure summary

Code : 2YBU   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human acidic chitinase in complex with bisdionin F
Release Data : 2011-06-08
Compound :
mol_id molecule chains synonym
1 ACIDIC MAMMALIAN CHITINASE A,B,C,D,E,F AMCASE, CHITINASE
ec: 3.2.1.14
fragment: CATALYTIC DOMAIN, RESIDUES 21-398
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA PASTORIS  (taxid:644223)
organ: LUNG
expression_system_strain: GS115
expression_system_vector_type: PLASMID
expression_system_plasmid: PPIC9
Authors : Sutherland, T.E., Andersen, O.A., Betou, M., Eggleston, I.M., Maizels, R.M., van Aalten, D., Allen, J.E.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.

Sutherland, T.E.,Andersen, O.A.,Betou, M.  et al.
(2011)  Chem. Biol.  18 : 569 - 579

PubMed: 21609838
DOI: 10.1016/j.chembiol.2011.02.017

Reaction

Chain : A, B, C, D, E, F
UniProt : Q9BZP6 (CHIA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. 3.2.1.14 PubMed:18824549, PubMed:19241384, PubMed:19435888
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