Brand  (β version)

PDB ID: 2Y6R

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
CTC 7-chlorotetracycline PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2Y6R   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of the TetX monooxygenase in complex with the substrate 7- chlortetracycline
Release Data : 2011-03-23
Compound :
mol_id molecule chains
1 TETX2 PROTEIN A,B,C,D
fragment: FAD-BINDING DOMAIN, RESIDUES 11-388
mutation: YES
Source :
mol_id organism_scientific expression_system
1 BACTEROIDES THETAIOTAOMICRON  (taxid:818) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Volkers, G., Palm, G.J., Weiss, M.S., Wright, G.D., Hinrichs, W.
Keywords : OXIDOREDUCTASE, ANTIBIOTIC RESISTANCE, FLAVIN, TIGECYCLINE, TETRACYCLINE DEGRADATION
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

Structural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.

Volkers, G.,Palm, G.J.,Weiss, M.S.  et al.
(2011)  FEBS Lett.  585 : 1061

PubMed: 21402075
DOI: 10.1016/J.FEBSLET.2011.03.012

Reaction

Chain : A, B, C, D
UniProt : Q93L51 (TETX_BACT4)
Reaction: EC: Evidence:
Physiological Direction:
a tetracycline + H(+) + NADPH + O2 = an 11a- hydroxytetracycline + H2O + NADP(+) - HAMAP-Rule:MF_00845, PubMed:15452119, PubMed:16128584, PubMed:23236139, PubMed:26097034, PubMed:28481346
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H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+) 1.14.13.231 PubMed:15452119, PubMed:26097034
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H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+) - PubMed:16128584
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H(+) + NADPH + O2 + oxytetracycline = 11a-hydroxy- oxytetracycline + H2O + NADP(+) - PubMed:15452119
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