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Ligands
Code Name Style Show Link
FM5 3-(N-hydroxyacetamido)-1-(3,4-dichlorophenyl)propylphosphonic acid
MN Manganese (II) ion
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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Code : 2Y1G   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted FR900098 analogue and manganese.
Release Data : 2011-06-29
Compound :
mol_id molecule chains synonym
1 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE A,B DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE
ec: 1.1.1.267
fragment: RESIDUES 24-412
Source :
mol_id organism_scientific expression_system
1 MYCOBACTERIUM TUBERCULOSIS  (taxid:83332) ESCHERICHIA COLI  (taxid:469008)
strain: H37RV
expression_system_strain: BL21(DE3)
expression_system_variant: STAR
expression_system_vector_type: PLASMID
expression_system_plasmid: PET101D-TOPO
Authors : Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Keywords : OXIDOREDUCTASE, DOXP/MEP PATHWAY
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase

Andaloussi, M.,Henriksson, L.M.,Wieckowska, A.  et al.
(2011)  J.Med.Chem  54 : 4964

PubMed: 21678907
DOI: 10.1021/JM2000085

The 1.9 A Resolution Structure of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, a Potential Drug Target.

Henriksson, L.M.,Bjorkelid, C.,Mowbray, S.L.  et al.
(2006)  Acta Crystallogr.,Sect.D  62 : 807

PubMed: 16790937
DOI: 10.1107/S0907444906019196

Structures of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.

Henriksson, L.M.,Unge, T.,Carlsson, J.  et al.
(2007)  J.Biol.Chem.  282 : 19905

PubMed: 17491006
DOI: 10.1074/JBC.M701935200

Chain : A, B
UniProt : A2VLK3
Reaction : -