Brand  (β version)

PDB ID: 2XZK

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
NO3 Nitrate ion PoSSuM
NA Sodium ion PoSSuM
CL Chloride ion PoSSuM
FKD 3-deoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid PoSSuM
K99 (2r,3r,4r,5r,6s)-2,3-bis(fluoranyl)-4,5-bis(oxidanyl)-6-[(1r,2r)-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2XZK   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : THE ASPERGILLUS FUMIGATUS SIALIDASE IS A KDNASE: STRUCTURAL AND MECHANISTIC INSIGHTS
Release Data : 2011-01-19
Compound :
mol_id molecule chains synonym
1 EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE A,B KDNASE
ec: 3.2.1.18
fragment: MATURE PROTEIN, RESIDUES 21-406
Source :
mol_id organism_scientific expression_system
1 ASPERGILLUS FUMIGATUS  (taxid:330879) ESCHERICHIA COLI  (taxid:511693)
strain: AF293
expression_system_strain: BL21
Authors : Telford, J.C., Yeung, J.H.F., Kiefel, M.J., Watts, A.G., Hader, S., Chan, J., Bennet, A.J., Moore, M.M., Taylor, G.L.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

The Aspergillus Fumigatus Sialidase is a Kdnase: Structural and Mechanistic Insights.

Telford, J.C.,Yeung, J.H.F.,Xu, G.  et al.
(2011)  J.Biol.Chem.  286 : 10783

PubMed: 21247893
DOI: 10.1074/JBC.M110.207043

Reaction

Chain : A, B
UniProt : Q4WQS0 (SIA_ASPFU)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 3.2.1.18 PubMed:20652740, PubMed:21247893
-