Brand  (β version)

PDB ID: 2XYW

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Ligands
Code Name Style Show Link
08S 3-chloro-6-fluoro-N-[2-[4-[(5-propan-2-yl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]ethyl]-1-benzothiophene-2-carboxamide PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Structure summary

Code : 2XYW   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy
Release Data : 2011-02-23
Compound :
mol_id molecule chains synonym
1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA A,B NUCI, NUCLEAR HORMONE RECEPTOR 1, NUCLEAR RECEPTOR SUBFAMILY 1 GROUP C MEMBER 2, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA, PPAR-DELTA, NUC1, PPAR-BETA
fragment: LIGAND BINDING DOMAIN, RESIDUES 165-441
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Marquette, J.-P., Mathieu, M.
Keywords : DNA-BINDING, TRANSCRIPTION, TRANSCRIPTION REGULATION, RECEPTOR, ACTIVATOR, ZINC-FINGER
Exp. method : X-RAY DIFFRACTION ( 3.14 Å )
Citation :

Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy

Keil, S.,Matter, H.,Schonafinger, K.  et al.
(2011)  Chemmedchem  6 : 633

PubMed: 21400663
DOI: 10.1002/CMDC.201100047

Reaction

Chain : A, B
UniProt : Q03181 (PPARD_HUMAN)
Reaction : -