Brand  (β version)

PDB ID: 2XR5

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Ligands
Code Name Style Show Link
07B Dimethyl (1s,2s,4s,5s)-4,5-dihydroxycyclohexane-1,2-dicarboxylate PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
ETA Ethanolamine PoSSuM
MAN Alpha-D-mannopyranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2XR5   PDBj   RCSB PDB   PDBe
Header : SUGAR BINDING PROTEIN
Title : Crystal structure of the complex of the carbohydrate recognition domain of human DC-SIGN with pseudo dimannoside mimic.
Release Data : 2011-10-19
Compound :
mol_id molecule chains synonym
1 CD209 ANTIGEN A DC-SIGN, DENDRITIC CELL-SPECIFIC ICAM-3-GRABBING NON-INTEGRIN 1, DC-SIGN1, C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER L, CD209, MDC-SIGN1A TYPE I
fragment: CARBOHYDRATE RECOGNITION DOMAIN, RESIDUES 254-404
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PASK-IBA7PLUS
Authors : Thepaut, M., Suitkeviciute, I., Sattin, S., Reina, J., Bernardi, A., Fieschi, F.
Keywords : SUGAR BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.42 Å )
Citation :

Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-Type Lectin Dc-Sign. Structural Requirements for Selectivity and Ligand Design.

Thepaut, M.,Guzzi, C.,Sutkeviciute, I.  et al.
(2013)  J.Am.Chem.Soc.  135 : 2518

PubMed: 23360500
DOI: 10.1021/JA3053305

Reaction

Chain : A
UniProt : Q9NNX6 (CD209_HUMAN)
Reaction : -