Brand  (β version)

PDB ID: 2XQJ

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
GLY Glycine PoSSuM
K Potassium ion PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
SO4 Sulfate ion PoSSuM
VX O-ethylmethylphosphonic acid ester group PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUL Beta-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 2XQJ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(R)
Release Data : 2011-03-23
Compound :
mol_id molecule chains synonym
1 CHOLINESTERASE A ACYLCHOLINE ACYLHYDROLASE, CHOLINE ESTERASE II, BUTYRYLCHOLINE ESTERASE, PSEUDOCHOLINESTERASE
ec: 3.1.1.8
fragment: RESIDUES 31-557
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_common: CHINESE HAMSTER
expression_system_cell_line: CHO K1
expression_system_plasmid: PGS
Authors : Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F.
Keywords : HYDROLASE, NERVE AGENT, BIOSCAVENGER
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-Agents.

Wandhammer, M.,Carletti, E.,Van Der Schans, M.  et al.
(2011)  J.Biol.Chem.  286 : 16783

PubMed: 21454498
DOI: 10.1074/JBC.M110.209569

Reaction

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an acylcholine + H2O = a carboxylate + choline + H(+) 3.1.1.8 PubMed:19368529, PubMed:19452557
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