Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
K Potassium ion
CL Chloride ion
NA Sodium ion
VX O-ethylmethylphosphonic acid ester group
FUL Beta-L-fucose
GLY Glycine
NAG N-acetyl-D-glucosamine
SO4 Sulfate ion
UNX Unknown atom or ion
Code : 2XQF
Header : HYDROLASE
Title : X-ray Structure of human butyrylcholinesterase inhibited by racemic VX
Release Data : 2011-03-23
Compound :
mol_id molecule chains synonym
1 CHOLINESTERASE A ACYLCHOLINE ACYLHYDROLASE, CHOLINE ESTERASE II, BUTYRYLCHOLINE ESTERASE, PSEUDOCHOLINESTERASE
ec: 3.1.1.8
fragment: RESIDUES 31-557
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_common: CHINESE HAMSTER
expression_system_cell_line: CHO K1
expression_system_plasmid: PGS
Authors : Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F.
Keywords : HYDROLASE, NERVE AGENT, BIOSCAVENGER
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-Agents.

Wandhammer, M.,Carletti, E.,Van Der Schans, M.  et al.
(2011)  J.Biol.Chem.  286 : 16783

PubMed: 21454498
DOI: 10.1074/JBC.M110.209569

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction : An acylcholine + H(2)O = choline + a carboxylate.