Brand  (β version)

PDB ID: 2XPC

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Ligands
Code Name Style Show Link
051 (1r,3r,4s)-4-[({6-[(4-cyano-2-fluorobenzyl)oxy]naphthalen-2-yl}sulfonyl)amino]cyclohexane-1,3-dicarboxylic acid PoSSuM
CL Chloride ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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KCX Lysine nz-carboxylic acid
Glycosylation
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Modification
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Structure summary

Code : 2XPC   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid
Release Data : 2011-05-18
Compound :
mol_id molecule chains synonym
1 UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE A UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE, D-GLUTAMIC ACID-ADDING ENZYME, MURD LIGASE
ec: 6.3.2.9
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:562) Escherichia coli DH5[alpha]  (taxid:668369)
cell_line: DH5A
expression_system_plasmid: PABD16/MURD
Authors : Sosic, I., Barreteau, H., Simcic, M., Sink, R., Cesar, J., Golic-Grdadolnik, S., Contreras-Martel, C., Dessen, A., Amoroso, A., Joris, B., Blanot, D., Gobec, S.
Keywords : LIGASE, CELL CYCLE, CELL DIVISION, CELL SHAPE, CELL WALL BIOGENESIS/DEGRADATION, LIGASE SYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 1.49 Å )
Citation :

Second-Generation Sulfonamide Inhibitors of D- Glutamic Acid-Adding Enzyme: Activity Optimisation with Conformationally Rigid Analogues of D- Glutamic Acid.

Sosi, I.,Barreteau, H.,Sim, M.  et al.
(2011)  Eur.J.Med.Chem  46 : 2880

PubMed: 21524830
DOI: 10.1016/J.EJMECH.2011.04.011

Reaction

Chain : A
UniProt : Q8X9Y9 (MURD_ECO57)
Reaction: EC: Evidence:
Physiological Direction:
UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + ADP + phosphate + H(+) 6.3.2.9 -
-