Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CL Chloride ion
VX O-ethylmethylphosphonic acid ester group
FUL Beta-L-fucose
NAG N-acetyl-D-glucosamine
NH4 Ammonium ion
SO4 Sulfate ion
UNX Unknown atom or ion
Code : 2XMG
Header : HYDROLASE
Title : G117H mutant of human butyrylcholinesterase in complex with VX
Release Data : 2010-12-01
Compound :
mol_id molecule chains synonym
1 CHOLINESTERASE A ACYLCHOLINE ACYLHYDROLASE, CHOLINE ESTERASE II, BUTYRYLCHOLINESTERASE, PSEUDOCHOLINESTERASE
ec: 3.1.1.8
fragment: RESIDUES 29-557
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_common: CHINESE HAMSTER
expression_system_cell_line: CHO K1
Authors : Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Keywords : GLYCOPROTEIN, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge

Nachon, F.,Carletti, E.,Wandhammer, M.  et al.
(2011)  Biochem.J.  434 : 73

PubMed: 21091433
DOI: 10.1042/BJ20101648

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction : An acylcholine + H(2)O = choline + a carboxylate.