Brand  (β version)

PDB ID: 2XMG

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
NH4 Ammonium ion PoSSuM
SO4 Sulfate ion PoSSuM
UNX Unknown atom or ion PoSSuM
VX O-ethylmethylphosphonic acid ester group PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUL Beta-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 2XMG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : G117H mutant of human butyrylcholinesterase in complex with VX
Release Data : 2010-12-01
Compound :
mol_id molecule chains synonym
1 CHOLINESTERASE A ACYLCHOLINE ACYLHYDROLASE, CHOLINE ESTERASE II, BUTYRYLCHOLINESTERASE, PSEUDOCHOLINESTERASE
ec: 3.1.1.8
fragment: RESIDUES 29-557
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_common: CHINESE HAMSTER
expression_system_cell_line: CHO K1
Authors : Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Keywords : GLYCOPROTEIN, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge

Nachon, F.,Carletti, E.,Wandhammer, M.  et al.
(2011)  Biochem.J.  434 : 73

PubMed: 21091433
DOI: 10.1042/BJ20101648

Reaction

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an acylcholine + H2O = a carboxylate + choline + H(+) 3.1.1.8 PubMed:19368529, PubMed:19452557
-