Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
DG 2'-deoxyguanosine-5'-monophosphate
MG Magnesium ion
DTP 2'-deoxyadenosine 5'-triphosphate
GOL Glycerol
Code : 2XJB
Header : HYDROLASE
Title : Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with deoxyguanosine monophosphate and deoxyadenosine triphosphate
Release Data : 2011-03-16
Compound :
mol_id molecule chains synonym
1 CYTOSOLIC PURINE 5'-NUCLEOTIDASE A CYTOSOLIC 5'-NUCLEOTIDASE II
ec: 3.1.3.5
fragment: RESIDUES 1-536
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: R3-PRARE2
expression_system_vector: P28A-LIC
Authors : Wallden, K., Nordlund, P.
Keywords : ALLOSTERIC ENZYME, CN-II, GMP-IMP SPECIFIC NUCLEOTIDASE, HIGH KM 5-PRIME NUCLEOTIDASE, HYDROLASE, METAL-BINDING, NT5C2, NUCLEOTIDE METABOLISM, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II

Wallden, K.,Nordlund, P.
(2011)  J.Mol.Biol.  408 : 684

PubMed: 21396942
DOI: 10.1016/J.JMB.2011.02.059

Chain : A
UniProt : P49902 (5NTC_HUMAN)
Reaction : A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.