Het-PDB Navi2 (PDB: 2XIR)

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Ligands
Code	Name		Style	Show	Link
00J	N,2-dimethyl-6-{[7-(2-morpholin-4-ylethoxy)quinolin-4-yl]oxy}-1-benzofuran-3-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2XIR

Code :

2XIR PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210 (N,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)

Release Data :

2011-04-13

Compound :

mol_id	molecule	chains	synonym
1	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	A	VEGFR-2, KINASE INSERT DOMAIN RECEPTOR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, FETAL LIVER KINASE 1, FLK-1, CD309
	ec: 2.7.10.1 fragment: KINASE DOMAIN, RESIDUES 806-939,990-1171 mutation: YES

Source :

mol_id	organism_scientific	organism_common
1	HOMO SAPIENS (taxid:9606)	HUMAN
	synthetic: yes

Authors :

McTigue, M., Wickersham, J., Pinko, C., Hong, Y., Marrone, T.

Keywords :

ANGIOGENESIS, NUCLEOTIDE-BINDING, INHIBITOR, PHOSPHORYLATION, RECEPTOR, TRANSFERASE, TRANSMEMBRANE

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Discovery of the Selective Vegfr Inhibitor Pf- 00337210

Mctigue, M.,Wickersham, J.,Marrone, T.
To be Published

Chain :

UniProt :

P35968 (VGFR2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632
	-	PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632

PDB ID: 2XIR

Hetero Atom Contents

Structure summary

Reaction