Brand  (β version)

PDB ID: 2XIQ

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Ligands
Code Name Style Show Link
B12 Cobalamin PoSSuM
5AD 5'-deoxyadenosine PoSSuM
MLC Malonyl-coenzyme a PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2XIQ   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA
Release Data : 2010-09-29
Compound :
mol_id molecule chains synonym
1 METHYLMALONYL-COA MUTASE, MITOCHONDRIAL A,B MCM, METHYLMALONYL-COA ISOMERASE
ec: 5.4.99.2
fragment: RESIDUES 12-750
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)-R3-PRARE2
expression_system_vector: PNIC28-CTHF
Authors : Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Ugochukwu, E., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Keywords : ORGANIC ACIDURIA, ISOMERASE, METABOLIC DISEASE, VITAMIN B12
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.

Froese, D.S.,Kochan, G.,Muniz, J.  et al.
(2010)  J.Biol.Chem.  285 : 38204

PubMed: 20876572
DOI: 10.1074/JBC.M110.177717

Reaction

Chain : A, B
UniProt : P22033 (MUTA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(R)-methylmalonyl-CoA = succinyl-CoA 5.4.99.2 PubMed:1346616, PubMed:1978672, PubMed:21138732, PubMed:24458, PubMed:2453061, PubMed:25125334, PubMed:27167370, PubMed:28101778, PubMed:28943303, PubMed:29056341
left-to-right PubMed:2453061