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Ligands
Code Name Style Show Link
C0Y (3-tert-butyl-4-hydroxyphenyl)morpholin-4-yl-methanone
Non-standard Residues
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Glycosylation
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Code : 2XHT   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Structure of HSP90 with small molecule inhibitor bound
Release Data : 2010-09-01
Compound :
mol_id molecule chains synonym
1 HEAT SHOCK PROTEIN HSP 90-ALPHA A HSP90, HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38
fragment: RESIDUES 9-236
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Murray, C.W., Carr, M.G., Callaghan, O., Chessari, G., Congreve, M., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham, B., McMenamin, R., OBrien, M.A., Patel, S., Phillips, T.R., Williams, G., Woodhead, A.J., Woolford, A.J.A.
Keywords : CHAPERONE, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.27 Å )
Citation :

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency.

Murray, C.W.,Carr, M.G.,Callaghan, O.  et al.
(2010)  J.Med.Chem.  53 : 5942

PubMed: 20718493
DOI: 10.1021/JM100059D

Chain : A
UniProt : P07900 (HS90A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.10 PubMed:12526792
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