Het-PDB Navi2 (PDB: 2XHR)

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Ligands
Code	Name		Style	Show	Link
C0P	4-chloro-6-[2,4-dichloro-5-(2-morpholin-4-ylethoxy)phenyl]pyrimidin-2-amine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2XHR

Code :

2XHR PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Structure of HSP90 with small molecule inhibitor bound

Release Data :

2010-09-01

Compound :

mol_id	molecule	chains	synonym
1	HEAT SHOCK PROTEIN HSP 90-ALPHA	A	HSP 86, RENAL CARCINOMA ANTIGEN NY-REN-38
	fragment: N-TERMINAL DOMAIN (9-236)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	gene: HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA expression_system_strain: BL21(DE3)

Authors :

Murray, C.W., Carr, M.G., Callaghan, O., Chessari, G., Congreve, M., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham, B., McMenamin, R., OBrien, M.A., Patel, S., Phillips, T.R., Williams, G., Woodhead, A.J., Woolford, A.J.A.

Keywords :

CHAPERONE, ATP BINDING DOMAIN, N-TERMINAL DOMAIN, STRESS RESPONSE

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency.

Murray, C.W.,Carr, M.G.,Callaghan, O. et al.
(2010) J.Med.Chem. 53 : 5942

PubMed: 20718493
DOI: 10.1021/JM100059D

Chain :

UniProt :

P07900 (HS90A_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + H2O = ADP + H(+) + phosphate	3.6.4.10	PubMed:12526792
ATP + H2O = ADP + H(+) + phosphate	-	PubMed:12526792

PDB ID: 2XHR

Hetero Atom Contents

Structure summary

Reaction