Brand  (β version)

PDB ID: 2XFP

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Ligands
Code Name Style Show Link
C15 N-dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ISN Isatin PoSSuM
XCG 2-(2-benzofuranyl)-2-imidazoline PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2XFP   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Isatin-inhibited human monoamine oxidase B in complex with 2-(2- benzofuranyl)-2-imidazoline
Release Data : 2010-10-06
Compound :
mol_id molecule chains synonym
1 Amine oxidase [flavin-containing] B A,B Monoamine oxidase type B,MAO-B
ec: 1.4.3.4
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Komagataella pastoris  (taxid:4922)
gene: MAOB
Authors : Bonivento, D., Milczek, E.M., McDonald, G.R., Binda, C., Holt, A., Edmondson, D.E., Mattevi, A.
Keywords : FLAVOPROTEIN, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.66 Å )
Citation :

Potentiation of ligand binding through cooperative effects in monoamine oxidase B.

Bonivento, D.,Milczek, E.M.,McDonald, G.R.  et al.
(2010)  J. Biol. Chem.  285 : 36849 - 36856

PubMed: 20855894
DOI: 10.1074/jbc.M110.169482

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2 - PubMed:20493079
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a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
left-to-right
dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
left-to-right
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:11753429
ECO:0000269 | PubMed:12913124
ECO:0000269 | PubMed:15027868
ECO:0000269 | PubMed:15710600
ECO:0000269 | PubMed:16366596
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