Brand  (β version)

PDB ID: 2XFH

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Ligands
Code Name Style Show Link
CL6 1-[(2-chlorophenyl)(diphenyl)methyl]-1h-imidazole PoSSuM
DMS Dimethyl sulfoxide PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
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Structure summary

Code : 2XFH   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.
Release Data : 2010-09-29
Compound :
mol_id molecule chains synonym
1 ERYTHROMYCIN B/D C-12 HYDROXYLASE A CYTOCROME P450 CYP113A1, CYTOCHROME P450 113A1
ec: 1.14.-.-
mutation: YES
Source :
mol_id organism_scientific expression_system
1 SACCHAROPOLYSPORA ERYTHRAEA  (taxid:1836) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET28B
Authors : Savino, C., Montemiglio, L.C., Gianni, S., Vallone, B.
Keywords : MONOXYGENASE, ERYTHROMYCIN A BIOSYNTHESIS, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.

Montemiglio, L.C.,Gianni, S.,Vallone, B.  et al.
(2010)  Biochemistry  49 : 9199

PubMed: 20845962
DOI: 10.1021/BI101062V

Reaction

Chain : A
UniProt : P48635 (ERYK_SACEN)
Reaction: EC: Evidence:
Physiological Direction:
erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+) 1.14.13.154 PubMed:7849045
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