Brand  (β version)

PDB ID: 2XD1

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Ligands
Code Name Style Show Link
CEF Cefotaxime, c3' cleaved, open, bound form PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 2XD1   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : ACTIVE SITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS
Release Data : 2010-05-26
Compound :
mol_id molecule chains
1 PENICILLIN-BINDING PROTEIN 1B A,B
ec: 2.4.1.129, 2.3.2.-
fragment: RESIDUES 101-125,323-791
mutation: YES
Source :
mol_id organism_scientific expression_system
1 STREPTOCOCCUS PNEUMONIAE  (taxid:171101) ESCHERICHIA COLI  (taxid:469008)
strain: R6
expression_system_strain: BL21(DE3)
expression_system_plasmid: PGEX4T1
Authors : Macheboeuf, P., Di Guilmi, A.M., Job, V., Vernet, T., Dideberg, O., Dessen, A.
Keywords : TRANSFERASE, PEPTIDOGLYCAN SYNTHESIS, ACYLTRANSFERASE, GLYCOSYLTRANSFERASE, CELL WALL, PEPTIDOGLYCAN
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins.

Macheboeuf, P.,Di Guilmi, A.M.,Job, V.  et al.
(2005)  Proc.Natl.Acad.Sci.USA  102 : 577

PubMed: 15637155
DOI: 10.1073/PNAS.0407186102

Reaction

Chain : A, B
UniProt : Q7CRA4 (Q7CRA4_STRR6)
Reaction: EC: Evidence:
Physiological Direction:
[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) 2.4.1.129 ARBA:ARBA00023988
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