Brand  (β version)

PDB ID: 2XCG

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Ligands
Code Name Style Show Link
FA8 [[(2r,3s,4s)-5-[(4as)-7,8-dimethyl-2,4-dioxo-4a,5-dihydrobenzo[G]pteridin-10-yl]-2,3,4-trihydroxy-pentoxy]-hydroxy-phosphoryl] [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl hydrogen phosphate PoSSuM
3PL 3-phenylpropanal PoSSuM
XCG 2-(2-benzofuranyl)-2-imidazoline PoSSuM
C15 N-dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2XCG   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Tranylcypromine-inhibited human monoamine oxidase B in complex with 2- (2-benzofuranyl)-2-imidazoline
Release Data : 2010-10-06
Compound :
mol_id molecule chains synonym
1 Amine oxidase [flavin-containing] B A,B Monoamine oxidase type B,MAO-B
ec: 1.4.3.4
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Komagataella pastoris  (taxid:4922)
gene: MAOB
Authors : Bonivento, D., Milczek, E.M., McDonald, G.R., Binda, C., Holt, A., Edmondson, D.E., Mattevi, A.
Keywords : FLAVOPROTEIN, MAOB, MITOCHONDRION, OXIDOREDUCTASE, TRANSMEMBRANE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Potentiation of ligand binding through cooperative effects in monoamine oxidase B.

Bonivento, D.,Milczek, E.M.,McDonald, G.R.  et al.
(2010)  J. Biol. Chem.  285 : 36849 - 36856

PubMed: 20855894
DOI: 10.1074/jbc.M110.169482

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine - PubMed:20493079
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an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
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dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
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