Het-PDB Navi2 (PDB: 2X6J)

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Ligands
Code	Name		Style	Show	Link
093	N-(5-(4-chloro-3-(2-hydroxy-ethylsulfamoyl)- phenylthiazole-2-yl)-acetamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2X6J

Code :

2X6J PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93

Release Data :

2010-04-07

Compound :

mol_id	molecule	chains	synonym
1	PHOSPHOTIDYLINOSITOL 3 KINASE 59F	A,B	GH13170P, VPS34
	ec: 2.7.1.137, 2.7.1.153, 2.7.1.154 fragment: HELICAL AND CATALYTIC DOMAINS, RESIDUES 258-949 mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	DROSOPHILA MELANOGASTER (taxid:7227)	FRUIT FLY	ESCHERICHIA COLI BL21(DE3) (taxid:469008)
	expression_system_variant: C41 RIPL

Authors :

Miller, S., Tavshanjian, B., Oleksy, A., Perisic, O., Houseman, B.T., Shokat, K.M., Williams, R.L.

Keywords :

TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 3.50 Å )

Citation :

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.

Miller, S.,Tavshanjian, B.,Oleksy, A. et al.
(2010) Science 327 : 1638

Chain :

A, B

UniProt :

Q9W1M7 (Q9W1M7_DROME)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)	2.7.1.137	PIRNR:PIRNR000587
	-	PIRNR:PIRNR000587

PDB ID: 2X6J