Het-PDB Navi2 (PDB: 2WXF)

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Ligands
Code	Name		Style	Show	Link
039	2-((9h-purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3h)-one				PoSSuM

Non-standard Residues
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Download interaction data: 2WXF

Code :

2WXF PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39.

Release Data :

2010-01-12

Compound :

mol_id	molecule	chains	synonym
1	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM	A	PI3-KINASE P110 SUBUNIT DELTA, PTDINS-3-KINASE P110, P110DELTA, PI3K
	ec: 2.7.1.153 fragment: RESIDUES 106-1044

Source :

mol_id	organism_scientific	organism_common	expression_system
1	MUS MUSCULUS (taxid:10090)	HOUSE MOUSE	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_cell_line: Sf21 expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PFASTBAC HTA

Authors :

Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.

Keywords :

TRANSFERASE, PHOSPHOPROTEIN, ISOFORM-SPECIFIC INHIBITORS, CANCER

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors

Berndt, A.,Miller, S.,Williams, O. et al.
(2010) Nat.Chem.Biol. 6 : 117

PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293

Chain :

UniProt :

Q3UDT3 (Q3UDT3_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+)	2.7.1.153	ARBA:ARBA00023981
	left-to-right	ARBA:ARBA00023981

PDB ID: 2WXF

Hetero Atom Contents

Structure summary

Reaction