Brand  (β version)

PDB ID: 2WQ7

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
Code Name Show
TDY 5-(methylamino)thymidine 5'-(dihydrogen phosphate)
Z 1-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)pyrimidin-2(1h)-one
Glycosylation
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Structure summary

Code : 2WQ7   PDBj   RCSB PDB   PDBe
Header : LYASE/DNA
Title : Structure of the 6-4 photolyase of D. melanogaster in complex with the non-natural N4-methyl T(6-4)C lesion
Release Data : 2010-02-23
Compound :
mol_id molecule chains synonym
1 RE11660P A 6-4 DNA PHOTOLYASE
ec: 4.1.99.3
fragment: RESIDUES 1-520
mol_id molecule chains
2 5'-D(*AP*CP*AP*GP*CP*GP*GP*TDYP*ZP*GP* CP*AP*AP*GP*T)-3' C
mol_id molecule chains
3 5'-D(*TP*AP*CP*CP*TP*GP*CP*GP*AP*CP* CP*GP*CP*TP*G)-3' D
Source :
mol_id organism_scientific expression_system
1 DROSOPHILA MELANOGASTER  (taxid:7227) ESCHERICHIA COLI  (taxid:562)
expression_system_strain: ROSETTA-GAMI PLYSS (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PDEST007 DERIVATIVE
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
Authors : Glas, A.F., Kaya, E., Schneider, S., Maul, M.J., Carell, T.
Keywords : LYASE-DNA COMPLEX, DNA REPAIR, DNA LESION, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization Into (6-4) Lesions.

Glas, A.F.,Kaya, E.,Schneider, S.  et al.
(2010)  J.Am.Chem.Soc.  132 : 3254

PubMed: 20166732
DOI: 10.1021/JA910917F

Reaction

Chain : A
UniProt : Q8SXK5 (Q8SXK5_DROME)
Reaction : -
Cofactor: Evidence: Note:
FAD ECO:0000256 | PIRSR:PIRSR602081-1
Binds 1 FAD per subunit.