Brand  (β version)

PDB ID: 2WP9

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
TEO Malate like intermediate PoSSuM
NA Sodium ion PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
CBE 2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2WP9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhB His207Thr mutant
Release Data : 2010-08-25
Compound :
mol_id molecule chains
1 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT A,E,I
ec: 1.3.5.1, 1.3.99.1
other_details: FAD ATOM C8M IS COVALENTLY LINKED TO NE2 OF SDHA HIS45
mol_id molecule chains
2 SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT B,F,J
ec: 1.3.5.1, 1.3.99.1
mutation: YES
mol_id molecule chains synonym
3 SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT C,G,K SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT, CYTOCHROME B-556
ec: 1.3.5.1
other_details: RESIDUES 8-129 MODELLED
mol_id molecule chains synonym
4 SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT D,H,L SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN
ec: 1.3.5.1
other_details: RESIDUES 11-115 MODELLED
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:562) ESCHERICHIA COLI  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: PLASMID
expression_system_plasmid: PFAS
mol_id organism_scientific expression_system
2 ESCHERICHIA COLI  (taxid:562) ESCHERICHIA COLI  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: PLASMID
expression_system_plasmid: PFAS
mol_id organism_scientific expression_system
3 ESCHERICHIA COLI  (taxid:562) ESCHERICHIA COLI  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: PLASMID
expression_system_plasmid: PFAS
mol_id organism_scientific expression_system
4 ESCHERICHIA COLI  (taxid:562) ESCHERICHIA COLI  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: PLASMID
expression_system_plasmid: PFAS
Authors : Ruprecht, J., Yankovskaya, V., Maklashina, E., Iwata, S., Cecchini, G.
Keywords : CELL INNER MEMBRANE, TRICARBOXYLIC ACID CYCLE, METAL-BINDING, TRANSMEMBRANE, FLAVOPROTEIN, OXIDOREDUCTASE, ELECTRON TRANSPORT
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Perturbation of the quinone-binding site of complex II alters the electronic properties of the proximal [3Fe-4S] iron-sulfur cluster.

Ruprecht, J.,Iwata, S.,Rothery, R.A.  et al.
(2011)  J. Biol. Chem.  286 : 12756 - 12765

PubMed: 21310949
DOI: 10.1074/jbc.M110.209874

Reaction

Chain : A, E, I
UniProt : P0AC41 (SDHA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 PubMed:19710024
-
Chain : B, F, J
UniProt : P07014 (SDHB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 -
-
Chain : C, G, K
UniProt : P69054 (DHSC_ECOLI)
Reaction : -
Chain : D, H, L
UniProt : P0AC44 (DHSD_ECOLI)
Reaction : -