Brand  (β version)

PDB ID: 2W8J

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Ligands
Code Name Style Show Link
PLS [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2W8J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : SPT with PLP-ser
Release Data : 2009-01-27
Compound :
mol_id molecule chains synonym
1 SERINE PALMITOYLTRANSFERASE A SPT
fragment: RESIDUES 2-420
Source :
mol_id organism_scientific expression_system
1 SPHINGOMONAS PAUCIMOBILIS  (taxid:13689) ESCHERICHIA COLI  (taxid:562)
Authors : Carter, L.G., Raman, M.C.C., Johnson, K.A., Campopiano, D.J., Naismith, J.H.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

The External-Aldimine Form of Serine Palmitoyltranserase; Structural, Kinetic and Spectroscopic Analysis of the Wild-Type Enzyme and Hsan1 Mutant Mimics.

Raman, M.C.C.,Johnson, K.A.,Yard, B.A.  et al.
(2009)  J.Biol.Chem.  284 : 17328

PubMed: 19376777
DOI: 10.1074/JBC.M109.008680

Reaction

Chain : A
UniProt : Q93UV0 (SPT_SPHPI)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA 2.3.1.50 PubMed:11279212, PubMed:17557831, PubMed:17559874, PubMed:19376777
left-to-right PubMed:11279212