Brand  (β version)

PDB ID: 2W1A

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Ligands
Code Name Style Show Link
CE1 O-dodecanyl octaethylene glycol PoSSuM
GOL Glycerol PoSSuM
MN Manganese (II) ion PoSSuM
PG4 Tetraethylene glycol PoSSuM
SO4 Sulfate ion PoSSuM
TSA 8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid PoSSuM
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Structure summary

Code : 2W1A   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/ISOMERASE
Title : Non-covalent complex between dahp synthase and chorismate mutase from Mycobacterium tuberculosis with bound tsa
Release Data : 2009-07-07
Compound :
mol_id molecule chains synonym
1 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE AROG A,B DAHP SYNTHETASE, PHENYLALANINE-REPRESSIBLE
ec: 2.5.1.54
mol_id molecule chains synonym
2 CHORISMATE MUTASE C,D RV0948C/MT0975
ec: 5.4.99.5
fragment: RESIDUES 16-105
Source :
mol_id organism_scientific expression_system
1 MYCOBACTERIUM TUBERCULOSIS  (taxid:83332) ESCHERICHIA COLI  (taxid:562)
strain: H37RV
expression_system_strain: KA13
expression_system_plasmid: PKTDS-HN
mol_id organism_scientific expression_system
2 MYCOBACTERIUM TUBERCULOSIS  (taxid:83332) ESCHERICHIA COLI  (taxid:562)
strain: H37RV
expression_system_strain: KA13
expression_system_plasmid: PKTCMM-H
Authors : Okvist, M., Sasso, S., Roderer, K., Gamper, M., Codoni, G., Krengel, U., Kast, P.
Keywords : TRANSFERASE-ISOMERASE COMPLEX, AROMATIC AMINO ACID BIOSYNTHESIS, MULTI-ENZYME COMPLEX, PROTEIN-PROTEIN INTERACTIONS, SHIKIMATE PATHWAY
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Structure and Function of a Complex between Chorismate Mutase and Dahp Synthase: Efficiency Boost for the Junior Partner.

Sasso, S.,Okvist, M.,Roderer, K.  et al.
(2009)  Embo J.  28 : 2128

PubMed: 19556970
DOI: 10.1038/EMBOJ.2009.165

Reaction

Chain : A, B
UniProt : O53512 (AROG_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7- phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate 2.5.1.54 PubMed:16288916
left-to-right
Chain : C, D
UniProt : P64767 (CHMU_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
chorismate = prephenate 5.4.99.5 PubMed:15737998, PubMed:18727669, PubMed:19556970
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