Brand  (β version)

PDB ID: 2W0H

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
SB Antimony (III) ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2W0H   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH
Release Data : 2009-04-28
Compound :
mol_id molecule chains
1 TRYPANOTHIONE REDUCTASE A,B
ec: 1.8.1.12
Source :
mol_id organism_scientific expression_system
1 LEISHMANIA INFANTUM  (taxid:5671) ESCHERICHIA COLI  (taxid:562)
Authors : Baiocco, P., Colotti, G., Franceschini, S., Ilari, A.
Keywords : FAD, LEISHAMNIA, ANTIMONIALS, FLAVOPROTEIN, REDUCED NADPH, OXIDOREDUCTASE, REDOX-ACTIVE CENTER, TRYPANOTHIONE METABOLISM
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Molecular Basis of Antimony Treatment in Leishmaniasis.

Baiocco, P.,Colotti, G.,Franceschini, S.  et al.
(2009)  J.Med.Chem.  52 : 2603

PubMed: 19317451
DOI: 10.1021/JM900185Q

Reaction

Chain : A, B
UniProt : A4HSF7 (A4HSF7_LEIIN)
Reaction: EC: Evidence:
Physiological Direction:
trypanothione + NADP(+) = trypanothione disulfide + NADPH + H(+) 1.8.1.12 ARBA:ARBA00049331
-
Cofactor: Evidence: Note:
FAD ECO:0000256 | PIRSR:PIRSR000350-3
Binds 1 FAD per subunit.