Brand  (β version)

PDB ID: 2VZ2

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Ligands
Code Name Style Show Link
C15 N-dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
MFG (1z)-4-(4-fluorophenyl)-2-methylidenebutan-1-imine PoSSuM
Non-standard Residues
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Structure summary

Code : 2VZ2   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human MAO B in complex with mofegiline
Release Data : 2008-12-16
Compound :
mol_id molecule chains synonym
1 AMINE OXIDASE [FLAVIN-CONTAINING] B A,B HUMAN MONOAMINE OXIDASE B, MAO-B, MONOAMINE OXIDASE TYPE B
ec: 1.4.3.4
other_details: COVALENT BOND BETWEEN FAD AND MOFEGILINE INHIBITOR
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA PASTORIS  (taxid:4922)
Authors : Bonivento, D., Mattevi, A.
Keywords : OXIDOREDUCTASE, INHIBITOR BINDING, FLAVOPROTEIN, MITOCHONDRION, TRANSMEMBRANE, HUMAN MONOAMINE OXIDASE, MITOCHONDRION OUTER MEMBRANE, FAD, FLAVIN, MEMBRANE, MOFEGILINE, ACETYLATION
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.

Milczek, E.M.,Bonivento, D.,Binda, C.  et al.
(2008)  J. Med. Chem.  51 : 8019 - 8026

PubMed: 19053775
DOI: 10.1021/jm8011867

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2 - PubMed:20493079
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a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
left-to-right
dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
left-to-right
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:11753429
ECO:0000269 | PubMed:12913124
ECO:0000269 | PubMed:15027868
ECO:0000269 | PubMed:15710600
ECO:0000269 | PubMed:16366596
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