Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FFO N-[4-({[(6s)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
GLY Glycine
MRD (4r)-2-methylpentane-2,4-diol
PLP Pyridoxal-5'-phosphate
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 2VMY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of F351GbsSHMT in complex with Gly and FTHF
Release Data : 2008-12-16
Compound :
mol_id molecule chains synonym
1 SERINE HYDROXYMETHYLTRANSFERASE A,B SHMT, SERINE METHYLASE
ec: 2.1.2.1
fragment: RESIDUES 1-405
mutation: YES
Source :
mol_id organism_scientific expression_system
1 BACILLUS STEAROTHERMOPHILUS  (taxid:1422) ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_vector: PRSET C
Authors : Rajaram, V., Pai, V.R., Bisht, S., Bhavani, B.S., Appaji Rao, N., Savithri, H.S., Murthy, M.R.N.
Keywords : TRANSFERASE, ONE-CARBON METABOLISM, PLP-DEPENDENT ENZYMES, SERINE TERNARY COMPLEX, PYRIDOXAL PHOSPHATE, F351G, FOLATE BINDING
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Structural and Functional Studies of Bacillus Stearothermophilus Serine Hydroxymethyltransferase: The Role of Asn(341), Tyr(60) and Phe(351) in Tetrahydrofolate Binding.

Pai, V.R.,Rajaram, V.,Bisht, S.  et al.
(2009)  Biochem.J.  418 : 635

PubMed: 19046138
DOI: 10.1042/BJ20081739

Chain : A, B
UniProt : Q7SIB6 (Q7SIB6_GEOSE)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine 2.1.2.1 HAMAP-Rule:MF_00051
-