Brand  (β version)

PDB ID: 2VIG

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
EDO 1,2-ethanediol PoSSuM
COS Coenzyme a persulfide PoSSuM
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Structure summary

Code : 2VIG   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human short-chain acyl CoA dehydrogenase
Release Data : 2007-12-25
Compound :
mol_id molecule chains synonym
1 SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, A,B,C,D,E,F,G,H SCAD, BUTYRYL-COA DEHYDROGENASE, ACYL COA DEHYDROGENASE
ec: 1.3.99.2
fragment: RESIDUES 30-412
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: R3-PRARE2
expression_system_plasmid: PNIC-CTHF
Authors : Pike, A.C.W., Pantic, N., Parizotto, E., Gileadi, O., Ugochukwu, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Oppermann, U.
Keywords : FATTY ACID METABOLISM, FAD, POLYMORPHISM, FLAVOPROTEIN, MITOCHONDRION, DISEASE MUTATION, LIPID METABOLISM, OXIDOREDUCTASE, BETA OXIDATION, TRANSIT PEPTIDE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase

Pike, A.C.W.,Pantic, N.,Parizotto, E.  et al.
To be Published 

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P16219 (ACADS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] 1.3.8.1 PubMed:21237683
left-to-right PubMed:11134486
butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] 1.3.8.1 PubMed:21237683
left-to-right PubMed:11134486
H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl- CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] - UniProtKB:Q3ZBF6
left-to-right PubMed:11134486
H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:21237683
left-to-right PubMed:11134486