Brand  (β version)

PDB ID: 2VAV

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Ligands
Code Name Style Show Link
CSC 4-(3-acetoxymethyl-2-carboxy-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-1-carboxy-butyl-ammonium PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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OAS O-acetylserine
Glycosylation
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Structure summary

Code : 2VAV   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of deacetylcephalosporin C acetyltransferase (DAC-Soak)
Release Data : 2008-09-23
Compound :
mol_id molecule chains synonym
1 ACETYL-COA--DEACETYLCEPHALOSPORIN C ACETYLTRANSFERASE A,B,C,D,E,F,G,H,I,J,K,L DCPC-ATF, DAC ACETYLTRANSFERASE, DAC-AT, DEACETYLCEPHALOSPORIN C ACETYLTRANSFERASE
ec: 2.3.1.175
Source :
mol_id organism_scientific expression_system
1 ACREMONIUM CHRYSOGENUM  (taxid:5044) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: PTWIN
Authors : Lejon, S., Ellis, J., Valegard, K.
Keywords : ACETYL TRANSFERASE, A/B- HYDROLASE FOLD, TRANSFERASE, ACYLTRANSFERASE, ACETYL COENZYME A, ANTIBIOTIC BIOSYNTHESIS, CEPHALOSPORIN BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

The last step in cephalosporin C formation revealed: crystal structures of deacetylcephalosporin C acetyltransferase from Acremonium chrysogenum in complexes with reaction intermediates.

Lejon, S.,Ellis, J.,Valegard, K.
(2008)  J. Mol. Biol.  377 : 935 - 944

PubMed: 18279889
DOI: 10.1016/j.jmb.2008.01.047

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : P39058 (CEFG_HAPCH)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA 2.3.1.175 PubMed:1569032
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