Brand  (β version)

PDB ID: 2V96

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Ligands
Code Name Style Show Link
CFQ 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 2V96   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of the unphotolysed complex of TcAChE with 1-(2- nitrophenyl)-2,2,2-trifluoroethyl-arsenocholine at 100K
Release Data : 2007-11-20
Compound :
mol_id molecule chains synonym
1 ACETYLCHOLINESTERASE A,B ACHE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common
1 TORPEDO CALIFORNICA  (taxid:7787) PACIFIC ELECTRIC RAY
variant: G2 FORM
organ: ELECTRIC ORGAN
tissue: ELECTROPLAQUE
Authors : Colletier, J.-P., Sanson, B., Royant, A., Specht, A., Nachon, F., Masson, P., Zaccai, G., Sussman, J.L., Goeldner, M., Silman, I., Bourgeois, D., Weik, M.
Keywords : SERINE ESTERASE, ALTERNATIVE SPLICING, ACETYLCHOLINESTERASE CAGED COMPOUNDS KINETIC CRYSTALLOGRAPHY PARTIAL Q-WEIGHTED DIFFERENCE REFINEMENT BACKDOOR, NEUROTRANSMITTER DEGRADATION, LIPOPROTEIN, GLYCOPROTEIN, CELL JUNCTION, SYNAPSE, MEMBRANE, HYDROLASE, GPI-ANCHOR
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Use of a 'Caged' Analog to Study Traffic of Choline within Acetylcholinesterase by Kinetic Crystallography

Colletier, J.-P.,Royant, A.,Specht, A.  et al.
(2007)  Acta Crystallogr.,Sect.D  63 : 1115

PubMed: 18007027
DOI: 10.1107/S0907444907044472

Reaction

Chain : A, B
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-