Brand  (β version)

PDB ID: 2V2Z

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CDM 4-diphosphocytidyl-2-C-methyl-D-erythritol PoSSuM
ADP Adenosine-5'-diphosphate PoSSuM
SO4 Sulfate ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2V2Z   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : IspE in complex with ADP and CDPME
Release Data : 2007-06-19
Compound :
mol_id molecule chains synonym
1 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE A,B CMK, 4-CYTIDINE-5'-DIPHOSPHO-2-C-METHYL-D-ERYTHRITOL KINASE
ec: 2.7.1.148
Source :
mol_id organism_scientific expression_system
1 AQUIFEX AEOLICUS  (taxid:63363) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: PET15B
Authors : Sgraja, T., Alphey, M.S., Hunter, W.N.
Keywords : TRANSFERASE, 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL, AQUIFEX AEOLICUS, NUCLEOTIDE-BINDING, ISOPRENE BIOSYNTHESIS, KINASE, ATP-BINDING, NON-MEVALONATE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Characterization of Aquifex Aeolicus 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase -Ligand Recognition in a Template for Antimicrobial Drug Discovery.

Sgraja, T.,Alphey, M.S.,Ghilagaber, S.  et al.
(2008)  FEBS J.  275 : 2779

PubMed: 18422643
DOI: 10.1111/J.1742-4658.2008.06418.X

Reaction

Chain : A, B
UniProt : O67060 (ISPE_AQUAE)
Reaction: EC: Evidence:
Physiological Direction:
4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D- erythritol 2-phosphate + ADP + H(+) 2.7.1.148 HAMAP-Rule:MF_00061
-