Brand  (β version)

PDB ID: 2V0D

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Ligands
Code Name Style Show Link
C53 2-imino-5-(1-pyridin-2-yl-meth-(E)-ylidene)-1,3-thiazolidin-4-one PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2V0D   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
Release Data : 2007-06-26
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE, CYCLIN DEPENDENT KINASE 2
ec: 2.7.1.37, 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_strain: SF21
expression_system_vector_type: BACULOVIRUS
Authors : Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Keywords : PHOSPHORYLATION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, CELL DIVISION, NUCLEOTIDE- BINDING, THIAZOLIDINONE LIGAND, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.

Richardson, C.M.,Nunns, C.L.,Williamson, D.S.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 3880

PubMed: 17570665
DOI: 10.1016/J.BMCL.2007.04.110

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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