Brand  (β version)

PDB ID: 2UZN

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Ligands
Code Name Style Show Link
C96 4-{5-[(1z)-1-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)ethyl]-2-furyl}benzenesulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2UZN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
Release Data : 2007-06-26
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE, CYCLIN DEPENDENT KINASE 2
ec: 2.7.11.22, 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_strain: SF21
expression_system_vector_type: BACULOVIRUS
Authors : Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Keywords : TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.

Richardson, C.M.,Nunns, C.L.,Williamson, D.S.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 3880

PubMed: 17570665
DOI: 10.1016/J.BMCL.2007.04.110

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:21565702
Binds 2 Mg(2+) ions.